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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
24.24
Human Site:
T409
Identified Species:
38.1
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
T409
P
L
V
A
E
T
D
T
P
N
R
A
T
F
V
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
T409
P
L
V
A
E
T
D
T
P
N
R
A
T
F
V
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
T409
P
L
V
A
E
T
D
T
P
N
K
A
T
F
V
Dog
Lupus familis
XP_536323
888
97475
T409
P
F
V
A
E
T
D
T
S
S
R
A
T
F
V
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
T409
P
L
V
V
E
A
E
T
T
S
R
A
T
F
V
Rat
Rattus norvegicus
P51639
887
96670
T409
P
L
V
A
E
A
E
T
S
G
R
A
T
F
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
S396
I
K
P
V
L
A
E
S
S
T
K
A
T
F
V
Frog
Xenopus laevis
P20715
883
96702
T406
I
K
P
L
P
L
E
T
S
P
K
A
K
F
I
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
P417
P
L
P
A
P
K
E
P
E
Q
K
S
T
F
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
L450
N
A
S
T
Q
T
D
L
L
P
L
R
H
R
L
Honey Bee
Apis mellifera
XP_623118
908
99432
Q420
W
I
D
G
K
E
E
Q
I
D
E
K
Q
C
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
K422
P
V
S
S
H
S
V
K
P
A
R
F
T
I
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
D153
A
P
E
K
M
P
E
D
D
E
E
I
V
A
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
E166
N
P
E
P
I
V
T
E
S
L
P
E
E
D
E
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
V566
T
V
I
S
G
S
K
V
K
S
L
S
S
A
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
93.3
80
N.A.
66.6
73.3
N.A.
N.A.
26.6
20
40
N.A.
13.3
0
N.A.
26.6
P-Site Similarity:
100
100
100
86.6
N.A.
80
80
N.A.
N.A.
46.6
40
60
N.A.
26.6
26.6
N.A.
46.6
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
0
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
0
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
40
0
20
0
0
0
7
0
54
0
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
0
0
7
0
0
0
34
7
7
7
0
0
0
7
0
% D
% Glu:
0
0
14
0
40
7
47
7
7
7
14
7
7
0
7
% E
% Phe:
0
7
0
0
0
0
0
0
0
0
0
7
0
60
0
% F
% Gly:
0
0
0
7
7
0
0
0
0
7
0
0
0
0
7
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
14
7
7
0
7
0
0
0
7
0
0
7
0
7
7
% I
% Lys:
0
14
0
7
7
7
7
7
7
0
27
7
7
0
0
% K
% Leu:
0
40
0
7
7
7
0
7
7
7
14
0
0
0
7
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
14
0
0
0
0
0
0
0
0
20
0
0
0
0
0
% N
% Pro:
54
14
20
7
14
7
0
7
27
14
7
0
0
0
0
% P
% Gln:
0
0
0
0
7
0
0
7
0
7
0
0
7
0
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
40
7
0
7
0
% R
% Ser:
0
0
14
14
0
14
0
7
34
20
0
14
7
0
7
% S
% Thr:
7
0
0
7
0
34
7
47
7
7
0
0
60
0
7
% T
% Val:
0
14
40
14
0
7
7
7
0
0
0
0
7
0
54
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _